Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma.

Acta Pharm Sin B · 2025 · PMC12278410 · PMID 40698127

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an increasing trendno p-value reported

Furthermore, IP experiments showed an increasing trend in the level of ubiquitinated EGFR/EGFRvIII when DPP4 was depleted ( Fig. 3 D and E).

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