A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.

Statistical significance was defined as ∗ P < 0.05, with highly significant differences denoted as ∗∗ P < 0.01, ∗∗∗ P < 0.001, and ∗∗∗∗ P < 0.0001. 3 Result and discussion 3.1 Preparation of HA-SF gel The HA-SF co-crosslinked injectable hydrogel was prepared using a potent chemical crosslinking method ( Fig. 1 A) employing BDDE: a crosslinking agent widely used in commercial products.

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