A single cysteine residue in vimentin regulates long non-coding RNA <i>XIST</i> to suppress epithelial-mesenchymal transition and stemness in breast cancer.

Elife · 2025 · PMC12279371 · PMID 40690373

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A highly significant observation was the upregulation of long non-coding RNA (lncRNA), XIST, in C328S-VIM-expressing MCF-7 cells, which are normally oestrogen-dependent for tumorigenesis ( Soule and McGrath, 1980 ), becoming oestrogen-independent by C328S-VIM in nude mice.

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A single cysteine residue in vimentin regulates long non-coding RNA &lt;i&gt;XIST&lt;/i&gt; to suppress epithelial-mesenchymal transition and stemness in breast cancer.

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A single cysteine residue in vimentin regulates long non-coding RNA <i>XIST</i> to suppress epithelial-mesenchymal transition and stemness in breast cancer.