Lung-resident SARS-CoV-2 peptide-specific immune responses in perfused 3D human lung explant models.

A decreasing trend was noted for the percentage of classical memory B cells in M-peptide-exposed COVID-19 + lung tissues compared to control and M-peptide exposure in UN tissues ( Figure 4D ).

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Although the percentage of PD-1 + CD4 + T cells did not change in COVID-19 + , the percentage of PD-1 + CD8 + T cells showed an increasing trend in COVID-19 + and negatively correlated with convalescence ( Figure 2E–G , Supplementary Figures S6A, S7A ).

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