Novel cancer subtyping method guided by tumor-normal sample in latent space of transcriptomic variational autoencoder.

In stark contrast, the subtypes identified by our VaDTN framework, which uses the true healthy tissue center, showed highly significant survival stratification for SKCM, BRCA, LIHC, and STAD.

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The borderline significance observed in LUSC and the lack of clear stratification in PAAD highlight the need for refinement and independent validation in specific tumor contexts.

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