Multi-omics analysis uncovers predictive biomarkers for the efficacy and outcomes of chemoimmunotherapy in advanced unresectable biliary tract cancers.

The mutation frequencies of BRCA2 and TP53 , as well as the TMB, were higher in the response group ( P = 0.002, 0.042, 0.072, respectively) and demonstrated a decreasing trend across the response status ( P = 0.002, 0.067, 0.008, respectively; Fig. 2 B–D).

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