Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma.

Nat Med · 2025 · PMC12283385 · PMID 40473950

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

of borderline significanceP = 0.09so close (0.05 < p ≤ 0.1)

Using the available tumor infiltration data from CM-067, we found some indication of increased pretreatment (baseline) CD8 + T cell tumor infiltration in HG-T compared to the other MT-HGs; however, these observations were of borderline significance ( P = 0.09).

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