Predicting acute and late toxicity in prostate cancer stereotactic ablative radiotherapy: the role of dosimetric parameters and prostate volume.

Strahlenther Onkol · 2025 · PMC12283893 · PMID 39792260

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

marginally significantp = 0.06so close (0.05 < p ≤ 0.1)

For late GU toxicity, the only predictor for grade 1–2 toxicity that was marginally significant was bladder D1% ( p = 0.06) and for grade 3–4 toxicity, bladder D15cc ( p = 0.09) in UVA.

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a trend towards significancep = 0.07so close (0.05 < p ≤ 0.1)

Furthermore, dose received by 10% and 1% of the bladder volume (D10% and D1%) showed a trend towards significance and were evaluated as clinically relevant predictors for grade 1–2 and grade 3–4 GU toxicity, respectively ( p = 0.07 and p = 0.05; Table 2 ).

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

Furthermore, dose received by 10% and 1% of the bladder volume (D10% and D1%) showed a trend towards significance and were evaluated as clinically relevant predictors for grade 1–2 and grade 3–4 GU toxicity, respectively ( p = 0.07 and p = 0.05; Table 2 ).

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may be significantno p-value reported

Our study suggested that volumes over 60 cc may be significant for acute grade 3–4 GU toxicity.

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