A Phosphatidylinositol 3-Kinase Gamma Inhibitor Enhances Anti-Programmed Death-1/Programmed Death Ligand-1 Antitumor Effects by Remodeling the Tumor Immune Microenvironment of Ovarian Cancer.

MedComm (2020) · 2025 · PMC12284418 · PMID 40703194

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.5750

boldest claim

The sentences

a decreasing trendp < 0.05actually significant

Moreover, the percentage of MDSCs decreased while the percentage of CD8 + T cells increased in the IPI‐549+anti‐PD‐1 group and showed a decreasing trend compared with the anti‐PD‐1 group for both PBMCs and MSLs (most Groups p < 0.05).

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an increasing trendp = 0.575not close (p > 0.1)

Briefly, the peritoneal cavity M1/M2 ratios of the mice in the IPI‐549 ( p = 0.085) groups were greater than those in the control group, and moreover, there was an increasing trend in the IPI‐549+anti‐PD‐1 group ( p = 0.575) compared with those in the anti‐PD‐1 group, although the difference was not statistically significant.

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