Importantly, this not only suggests mitochondrial damage due to Aβ42 production, but this phenomenon observed in both lines (APP Swe/Ind and HSD10 cell lines) may be highly significant in the context of AD.
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New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease.
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