138 Meanwhile, Staphylococcus aureus is known to be able to greatly increase its virulence by developing antimicrobial resistance, and indeed a worrying trend of increasing methicillin-resistant Staphylococcus aureus infections has been observed, 135 accounting for up to 7.5% of all infections according to a large IE database in Japan. 141 Several risk scores have been developed to predict risk of IE in patients with Staphylococcus aureus bacteremia.
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