Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy.

Dual producing IL-21 + IFN-γ + Tfh cells were increased within the islets of anti–PD-1 treated mice ( Figure 1I , P < 0.01), with a nonsignificant trend within the islets for increased IL-21 + IFN-γ – Tfh cells ( Figure 1I , P = ns).

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