Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia.

JCI Insight · 2025 · PMC12288905 · PMID 40626362

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0.0009

closest p · 0.0× alpha

0.0009

boldest claim

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highly significantP = 0.0009actually significant

Statistical analysis revealed a highly significant interaction between sex and treatment (sham, LPS, or LPS plus DCA) ( P = 0.0009), indicating that the treatment effect on cardiac performance is sex specific.

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