Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome.

JCI Insight · 2025 · PMC12288962 · PMID 40526438

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a decreasing trendno p-value reported

Immunophenotyping of P2 and P3 revealed low levels of CD8 + T cells, innate lymphoid cells, CD4 + terminally differentiated effector memory cells re-expressing CD45RA (TEMRA), and circulating follicular helper T (cTfh) cells, as well as a decreasing trend in γδT cells, NK cells, CD4 + central memory cells, CD4 + effector memory cells, and class-switched memory B cells.

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