The findings are both theoretically and practically significant in medical microbiology. 10.7554/eLife.101938.3.sa1 Reviewer #1 (Public review): Reviewer Summary: In this study, the authors sequenced emm89 serotype genomes of clinical isolates from patients in Japan, where the number of invasive Group A Streptococcus (GAS), especially those of the emm89 serotype, has drastically increased over the past 10-15 years.
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Identifying genetic variations in <i>emm</i>89 <i>Streptococcus pyogenes</i> associated with severe invasive infections.
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