19 , 20 , 21 Perplexingly, both in this trial, 19 and several previous retrospective/nonrandomized studies, 22 , 23 , 24 , 25 , 26 , 27 HU resulted in negligible/small increases in fetal Hb (HbF) in patients with HbSC-SCD, but showed highly significant clinical benefit in SCD symptoms 19 , 22 , 23 , 24 , 25 , 26 , 27 through an unknown mechanism.
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A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea.
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