Barely Significant
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Diagnostic and Prognostic Roles of miR-155 and miR-3173 in Breast and Ovarian Cancer: Implications for Early Detection and Personalized Treatment.

Biomedicines · 2025 · PMC12292438 · PMID 40722677

3
hedged sentences
0.0010
closest p · 0.0× alpha
0.0590
boldest claim

The sentences

highly significantp < 0.001actually significant
The statistical test (Z = 4.782) confirms a highly significant difference ( p < 0.001*) in miR-155 expression between cancer and normal tissues ( Figure 1 ).

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a trend toward significancep = 0.059so close (0.05 < p ≤ 0.1)
However, there was a trend toward significance for neoadjuvant treatment ( p = 0.059) and response to neoadjuvant therapy ( p = 0.065), with higher mean miR-3173 expression observed in patients who received neoadjuvant treatment and those with response scores of 4-5. miR-3173 expression was also higher in grade III tumors (9.62 ± 7.11) compared to grade II (3.93 ± 4.53) and grade I (1.04) tumors, although this difference was not statistically significant ( p = 0.174).

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a slight trendno p-value reported
Although there is a slight trend suggesting that higher expression might be associated with worse survival, this difference was not strong enough to be considered meaningful.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.