Maternal Nutrient Excess Induces Stress Signaling and Decreases Mitochondrial Number in Term Fetal Baboon Skeletal Muscle.

In this study, SIRT1 and SIRT3 transcript levels were both lower in the soleus muscle of MNE fetuses ( p < 0.05, Figure 6 A) and while only a decreasing trend was observed for SIRT1 protein levels ( Figure 6 B), SIRT3 levels were lower in MNE fetal soleus muscle ( p < 0.05, Figure 6 B), with possible implications for mitochondrial oxidative capacity and function regulation. 3.5.

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