Barely Significant
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The Complex Gene-Carbohydrate Interaction in Type 2 Diabetes: Between Current Knowledge and Future Perspectives.

Nutrients · 2025 · PMC12301066 · PMID 40732974

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borderline significantno p-value reported
In contrast, the case–cohort European Prospective Investigation into Cancer and Nutrition (EPIC)—InterAct study (a multi-center, prospective, cohort study of 519,978 participants from 8 European countries aimed at investigating the relationship of environmental factors, food habits and lifestyle with cancer and other chronic diseases), including 12,403 incident T2D cases and a random subcohort of 16,835 subjects, did not reveal significant effect modifications of TCF7L2 variants in the association between cereal fiber and T2D, except for a borderline significant protective association among carriers of TCF7L2 rs12255372 GG [ 145 ].

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