Correlation between plasma leptin and CCL2 and in vitro effects of leptin on ASCs We observed a highly significant correlation between plasma leptin levels and the expression of CCL2/MCP‐1, both in circulation (Figure 5A ) and in vWAT and ASCs (mRNA transcripts; Figure 5B,C ).
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Effects of obesity-associated plasma markers on adipose stem cell function and epigenetic regulation.
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Furthermore, studies suggest that preadipocytes and ASCs may be significant sources of proinflammatory mediators, such as CCL2 [ 12 ].