Our study found no significant changes in lung mechanics in this cohort after receiving all three within 24 hours of each other but did note a positive trend in lung compliance in the first 4 days suggesting the combined use of these therapies might help reduce elastic resistance in lung tissue, a measure related to work or breathing and is useful in understanding disease progression and ventilator management[ 43 , 44 ].
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Impact of proning with and without inhaled pulmonary vasodilators and neuromuscular blocking agents in COVID acute respiratory distress syndrome.
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The combination of PPV, IVd, and NMBA significantly improved tidal compliance on day 2, with an overall trend showing improvement in ventilator parameter over the 7 days; however, only day 2 reached significance.