Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity.

When combining HER2 scores with ISH, the IHC positive and low (HER2 1 +, 2 +, 3 +) rates of the initial diagnosed group were 64%, while the Nby-Aby diagnosed was 89%, and indicated a highly significant difference ( P < 0.001).

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