Interestingly, we found that the number of functionally identified putative excitatory neurons (i.e., those in which the APP family was specifically deleted), in the cortex of cTKO mice, was markedly and significantly reduced compared with controls, with a borderline significant reduction in CA1 ( Figure 3H ).
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The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo.
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