Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction.

The staining intensity of both p62 (Figure 6c ) and ubiquitin (Figure 6d ) although showing an increasing trend in SOD1 microglia compared to controls, was not statistically significant. 3.7 A Transient Increase in Autophagy Flux in Symptomatic SOD1 Spinal Astrocytes, to a Level Exceeding Microglia Deficit GFAP labeled spinal astrocytes contained autophagosomes and autolysosomes which were morphologically similar with no observable differences between SOD1 and control mice (Figure 7a,c,e ).

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