Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.

While we found no effect of optical stimulation of DRN DAT terminals on locomotion or time in center in the OFT ( Figure 3—figure supplement 1 ), we found stimulation of DRN DAT terminals in the BNST (but not in the CeA or BLP) resulted in a weak trend toward increased time spent in the open arm of the EPM ( Figure 3A–C ), which can be interpreted as exploratory behavior linked with a vigilant state ( Rodgers and Dalvi, 1997 ).

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