Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis.

This may be significant as IL1-β -mediated inflammation appears critical in accumulation of basaloid intermediates (or damage-associated transient progenitors, DATP) in murine models of alveolar injury 10 .

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Thus, despite highly significant and strong correlation in abundance between ABIs and the immune cells, CD103 + CD4 T cells and neutrophils at the leading edge of disease (Intm stage) (Fig. 2l, m ), neither cell types were spatially associated with ABIs in this disease stage. g ( r ) plot for CD206 hi macrophages - ABI_b-DC ADJ pairs showed the same qualitative distribution across the three disease stages (Fig. 3c )—the peak in co-location (‘g_max’) for CD206 hi macrophages-ABI_b-DC ADJ cell pair was found near the centroid of ABI_b-DCs, indicating stronger co-location above CSR nearer to ABI.

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