Artificial liver support with Cytosorb and continuous veno-venous hemodiafiltration versus advanced organ support (ADVOS) for critically ill patients with hyperbilirubinemia and acute-on-chronic liver failure (ACLF).

Otherwise, we observed a slight trend toward higher median duration of CRRT using ADVOS lasting 96 h in comparison to the median duration of continuous hemodialysis treatment among patients in the CytoSorb group lasting only 72 h, that might partly explain a better removal of serum creatinine and blood urea nitrogen under ADVOS than under CytoSorb with CVVHDF.

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