Effect of Perioperative Subanesthetic Dose of Esketamine on Postoperative Recovery Quality in Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial.

The difference of QoR-40 on POD 5 was statistically significant, but not clinically significant. Changes in Postoperative Pain Intensity The resting NRS scores of the esketamine group were significantly lower than those of the control group at 6 hours post-surgery ( Z =−6.322, P < 0.05), at 24 hours post-surgery ( Z =−5.736, P < 0.05), at 36 hours post-surgery ( Z =−6.563, P < 0.05), at 48 hours post-surgery ( Z =−5.920, P < 0.05) ( Figure 3 ). Changes in Plasma IL-6, TNF-α, and BDNF During Perioperative Period Compared to T0, plasma levels of IL-6 and TNF-α in two groups showed an increasing trend at T1 and T2; however, there were no significant differences between the two groups at the various time points ( P > 0.05) ( Figure 4A and B ).

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