Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations.

The model indicated a significant increase in mutation frequency with age in blood, a marginally significant increase in saliva, and no difference in oocytes ( Z test P = 2.7 × 10 −3 , P = 5.7 × 10 −2 , and P = 0.688 for blood, saliva, and oocytes, respectively; Fig. 1B and table S4).

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