highly significantP < 0.01
Differences were considered statistically significant at * P < 0.05, and highly significant at ** P < 0.01, *** P < 0.001, **** P < 0.0001, ns, not significant.
Differences were considered statistically significant at * P < 0.05, and highly significant at ** P < 0.01, *** P < 0.001, **** P < 0.0001, ns, not significant.