Blood levels of copper, manganese, selenium, and zinc are positively associated with cognitive function and academic performance in adolescents.

The difference in the SPM score across the quartiles of Se and Zn were marginally significant ( p = 0.08 for Se and 0.06 for Zn).

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It is of interest to note that although the median differences across the quartiles of Se and Zn were marginally significant ( Figure 1 ), after adjusting for other confounding variables (Model 4), the associations became highly significant.

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