Effects of Ricinoleic Acid (Castor Oil) on Gut Permeability in Healthy Participants: Provocative Test for Treatments Aimed at Restoring Barrier Function.

Clin Transl Gastroenterol · 2025 · PMC12330349 · PMID 40434309

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0870

boldest claim

The sentences

borderline significantP = 0.060so close (0.05 < p ≤ 0.1)

RESULTS: Permeability analysis across all groups demonstrated significant difference among the groups for 0–2 hours 13 C-mannitol, 0–24 hours 13 C-mannitol, and borderline significant difference for 2–8 hours 13 C-mannitol ( P = 0.060) and 0–24 hours lactulose ( P = 0.056).

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trend toward significanceP = 0.087so close (0.05 < p ≤ 0.1)

There was trend toward significance ( P = 0.087) for the 3,000 mg group for our primary endpoint, 2–8 hour urinary excretion of 13 C-mannitol.

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