highly significantp = 1.5 × 10 –16
Highly significant increases in median nFLAIR, CNI, and CCrI were observed for NAV→NEL ( p = 1.5 × 10 –16 , 2.4 × 10 –15 , 2.8 × 10 –16 , respectively) voxels compared to stable NAV voxels, while increases in median nADC also reached a statistical significance of p = 0.0009.