Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins.

Consistently, immunocytochemistry in HeLaS3 cells confirmed increased hnRNP A1 fluorescence in FLAG-hnRNP K–positive cells, while hnRNP A2/B1 showed a nonsignificant trend toward increased levels ( Fig. 6, B and C ).

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