UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells.

Nat Commun · 2025 · PMC12335541 · PMID 40783491

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To test this hypothesis, we re-analyzed the RNA-seq data from Dnmt1 -cKO PGCs 24 and found a highly significant overlap between the genes upregulated in Uhrf2 -/- and Dnmt1 cKO female PGCs (Fig. 4g ).

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