Barely Significant
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Varicocele grade does not correlate with the severity of sperm DNA fragmentation levels nor with the amount of improvement in DNA fragmentation following varicocele repair.

Transl Androl Urol · 2025 · PMC12336730 · PMID 40800085

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As far as outcomes that were not quite statistically significant but may represent a trend, were men with grade 3 varicoceles had a trend towards a lower percentage of sperm with normal morphology in comparison to men with grade 2 varicoceles: 2.6% and 4.3% normal morphology respectively (P value =0.055); and that the difference in severity of SDF in men with grade 3 varicoceles being higher than those with grade 2 varicoceles, indicated a trend, although not quite statistically significant (P=0.051).

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