Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the Lmna<sup>G609G/G609G</sup> Mouse Model of Progeria.

In addition, we found a highly significant decrease in BV/TV in the primary spongiosa of Lmna G609G/G609G bones compared to Lmna +/+ at both ages (-23%, p=0.001 and -38%, p=0.002, respectively) confirming the optical assessment of a thinner hypertrophic zone in few animals ( Supplementary Fig 4 ).

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