Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder.

The correlation coefficients were statistically significant for the left NAc subregions (core: r = −0.333, p = 0.024; shell: r = −0.297, p = 0.045) and marginally significant for the right NAc subregions (core: r = −0.257, p = 0.085; shell: r = −0.287, p = 0.053). 3.5. rsFC analysis between pre- and post-treatment in patients In the MDD group, the four NAc subregions showed increased rsFC with the bilaterial MCC, medial frontal gyrus, right putamen, and cerebellum after antidepressant treatment (voxel-level p < 0.001, cluster size ≥ 20 voxels).

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The observed rsFC changes following treatment likely reflect a generalized response across all treated MDD patients, representing an overall trend of strengthened connectivity within the patient population.

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