Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs.

There was a borderline significant difference ( p = 0.025) in the sensitivities of the 3D7 and Dd2 strains to 8-azaguanine but not to the other purine nucleobases ( Table 1 ) and we conclude that purine derivates are not cross-resistant with chloroquine.

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