Early cerebrospinal fluid elevations of pTau-217 in severe traumatic brain injury subjects.

Front Neurol · 2025 · PMC12344560 · PMID 40808925

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

borderline significantp = 0.054so close (0.05 < p ≤ 0.1)

A borderline significant positive correlation was observed between initial GCS scores and pTau-217 levels at 24–48 h ( p = 0.054, r=0.43).

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highly significantno p-value reported

While this methodological difference is an explicit limitation, the fact that we still observed a highly significant elevation in pTau-217 in the sTBI cohort makes our findings more robust, as the comparison was inherently conservative.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.