ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy.

mBio · 2025 · PMC12345148 · PMID 40693792

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highly significantno p-value reported

There was a highly significant increase in T reg cells in RdRp tg/– mice compared to WT and specifically an increase in mature, effector T regs ( Fig. 1E ).

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