Topical MTH1 Inhibition Suppresses SKP2-WNT5a-Driven Psoriatic Hyperproliferation.

Int J Mol Sci · 2025 · PMC12346197 · PMID 40806307

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markedly significantno p-value reported

These findings were further validated by qPCR, which revealed a markedly significant decrease in the mRNA levels of SKP2 , CDK4 , and PCNA , along with an increase in CDKN1A expression upon TH1579 treatment ( Figure 4 b).

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