Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning.

A Wilcoxon rank sum test indicated a highly significant difference in fitness variation ( W = 3.2 × 10 8 and P < 2.2 × 10 −16 ), supported by Welch’s t test, which showed a lower mean absolute fitness difference for closely related homologs compared to distantly related homologs ( t = −63.5, df = 7,020, and P < 2.2 × 10 −16 ; table S9).

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