Late-Life Short-Term Dietary Restriction Improves Intestinal Stem Cell Function and Alters Intestinal Stem Cell Deoxyribonucleic Acid Methylation in Mice.

J Nutr · 2025 · PMC12346696 · PMID 40456408

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AL-O and stDR mice showed an increase in overall methylation of the cis -and trans -acting region of the Cd2 gene, but when we evaluated the mCG concentrations of –500 to +500 region around the TSS ( Supplemental Figure 9D ), we did not find any difference in the AL-O mice but observed an increasing trend in stDR-young mice and a significant increase in stDR-old mice.

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