Comprehensive genetic profiling using tissue and blood in locally advanced tumors.

Oncol Rep · 2025 · PMC12351229 · PMID 40776748

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may be significantno p-value reported

Additionally, the use of fresh frozen samples for tumor tissue instead of FFPE marginally increased the concordance rate from 57.1 to 66.7%, suggesting fragmentation of DNA in FFPE processing may be significant, particularly when the detection assay relies on amplicon-based amplification ( 29 ).

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