Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.

Front Immunol · 2025 · PMC12351402 · PMID 40821801

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hedged sentence

0.0535

closest p · 1.1× alpha

0.0535

boldest claim

The sentences

marginally significantp=0.0535so close (0.05 < p ≤ 0.1)

More importantly, a marginally significant reduction in fold-change of lung CFUs was observed in the 12.5 μg Fc-E430G DMAb ( p=0.0535 ) when compared to Fc-WT DMAb with a significant reduction in the nasal wash in animals given 25 μg Fc-E430G ( p=0.0316 ) compared to WT-Fc ( Figures 5E, G ; Supplementary Figures S2 and S3 ).

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