Plasma proteomics links brain and immune system aging with healthspan and longevity.

We discovered highly significant associations between heart aging and atrial fibrillation (s.d. increase in heart age gap, hazard ratio (HR) = 1.75, q < 1 × 10 −250 ) and heart failure (s.d. increase in heart age gap, HR = 1.83, q = 8.35 × 10 −231 ), pancreas aging and kidney aging with chronic kidney disease (s.d. increase in pancreas age gap, HR = 1.80, q = 3.36 × 10 −247 ; s.d. increase in kidney age gap HR = 1.66, q = 2.85 × 10 −228 ), brain aging with Alzheimer’s disease (s.d. increase in brain age gap, HR = 1.80, q = 1.21×10 −67 ) and lung aging with COPD (s.d. increase in lung age gap, HR = 1.39, q = 6.82 × 10 −49 ).

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