Barely Significant
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Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.

Nat Commun · 2025 · PMC12354765 · PMID 40813364

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highly significantno p-value reported
The interaction model in APOE ε3/ε3 shows no significant p value for 19q13.31 :rs10423769-A in Africans, NOCT :rs13116075-G in African Admixed ancestry, CASS4 :rs6024870-A in Complex Admixed History, and LRRC37A :rs2732703-G in American Admixed ancestry, but highly significant p values for APOE :rs449647-T and TOMM40 :rs11556505-T in European and NOCT :rs13116075-G in Africans, with opposite directional effects compared to APOE ε4 carriers.

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