Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation.

In fact, compared to NCD feeding, HFD itself increased ASC death in M- Tipe2 +/+ mice, largely due to its contribution to TIPE2 loss in macrophages; even in NCD condition, TIPE2 deficiency in macrophages also caused an increasing trend of ASC death (Supplementary Fig. 6f–h ).

also in 63,971 other papers