4‑Hydroxyacetophenone is an Antipigmentation Reagent via Inhibiting Tryrosinase Activity.

2.2 4-HAP Exhibits Whitening Activity in Both the Zebrafish In Vivo Model and the In Vitro Models of Mushroom Tyrosinase and B16 Mouse Melanoma Cells In experiments utilizing the mushroom tyrosinase model, we observed a decreasing trend in tyrosinase activity with increasing concentrations of 4-HAP ( Figure A).

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